by clicking the "Next" arrow.
by clicking on the page.
the page around when zoomed in by dragging it.
the zoom using the slider when zoomed-in.
by clicking on the zoomed-in page.
by entering text in the search field, and select "This Issue" or "All Issues"
by clicking on thumbnails to select pages, and then press the print button.
displays sections with thumbnails and descriptions.
displays a slider of thumbnails. Click on a page to jump.
allows you to browse the full archive.
about your subscription?
Mindful : August 2019
inflammatory diseases, says Melissa Rosenkranz, PhD, associate scientist, Center for Healthy Minds, Univer- sity of Wisconsin–Madison. When you’re under psychological stress, your nerve endings release substance P, a chemical “messenger” that acts on immune and other cells to create inflammation, notes Dr. Rosenkranz in her study. Mindfulness (and po- tentially other meditation practices) combats this type of inflammation by helping to “train the mind to not get caught up in the story that we construct about the events of our lives,” says Dr. Rosenkranz. In other words, it’s reducing our reactivi- ty to stressful events that lessens inflammation. PREVENTIVE MEDICINE In addition to decreasing in- flammation, meditation may be a key in keeping it from developing in the first place. Suppose you inherit a set of genes from your par- ents that could predispose you to developing type 2 diabetes, for example. It’s not a forgone conclusion that you’ll automatically become diabetic at some point in your life, because gene expression—whether those genes will activate to trigger diabetes—is affected by the food you eat, your stress levels, the amount of exercise you get, and many other environmental factors, says Parneet Pal, MBBS, MS, Chief Science Officer at Wis- dom Labs in San Francisco. Recently, Dr. Pal led a small pilot study to track the effects of a 12-week mindfulness program in the workplace. Before and after her study, Dr. Pal’s research team measured the changes in the participants’ gene ex- pression on a set of 53 genes related to inflammation and immunity. These particular genes trigger inflammation and lower immunity when the body is under stress. After 12 weeks of a regular mindfulness practice, Dr. Pal said that among the partic- ipants, “there was a signifi- cantly lower expression of inflammatory genes and a greater expression of genes boosting immunity. Beyond that, participants also expe- rienced improved levels of social well-being—they felt better,” noted Dr. Pal. “The practice of mindful- ness,” adds Dr. Rosenkranz, “is about changing your relationship to life’s slings and arrows—not about keeping them at bay. A re- duction in inflammation, as a consequence of mindful- ness practice, is a fortunate side effect.” ● “THE EVIDENCE IS STRONG THAT MINDFULNESS— ESPECIALLY THE MORE YOU PRACTICE— 'DOWNREGULATES’ INFLAMMATORY GENES.” LEONARD H. CALABRESE, DO, PROFESSOR OF MEDICINE, CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE 24 mindful August 2019 mindful health